Performance evaluation of the nanoScan^® P123S total-body PET

Area of Science:

• Preclinical imaging
• Positron Emission Tomography (PET)
• Medical imaging technology

Background:

• Preclinical PET systems require performance evaluation for biological studies.
• The nanoScan® PET/CT P123S is a new extended field of view (FOV) system designed for rodent total-body PET applications.

Purpose of the Study:

• To assess the performance of the extended FOV nanoScan® PET/CT P123S system.
• To qualify the scanner's suitability for rodent total-body PET applications.

Main Methods:

• Evaluated spatial resolution, noise equivalent count rate (NECR), sensitivity, and image quality using NEMA NU-4 2008 protocols.
• Conducted Derenzo phantom and linearity measurements.
• Performed in vivo studies to assess biological application performance.

Main Results:

• Achieved spatial resolution under 0.7 mm with iterative reconstruction.
• NECR peaks were 1805.0 kcps (mouse phantom) and 880.7 kcps (rat phantom).
• Absolute sensitivity was 10.5%, with quantitative bias <4% and linear response up to 105 MBq.

Conclusions:

• The extended FOV PET system demonstrates improved sensitivity and count rate performance.
• Spatial resolution and quantitative accuracy are suitable for preclinical PET applications.
• The extended FOV facilitates total-body imaging in mice and rats.