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Updated: Jan 7, 2026

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
Synergistic use of high-resolution flow-sensitive and flow-compensated MRI sequences for the evaluation of
William Clackett1,2, Avinash K Kanodia1,2, Heinke Pulhorn3
1University of Dundee, Dundee, UK.
Abstract:
In the assessment of cerebrospinal fluid flow disorders such as aqueductal stenosis, Chiari malformation, and post-operative complications, conventional imaging often falls short in resolving subtle anatomical and dynamic nuances. This case series explores the value of integrating high-resolution flow-sensitive and flow-compensated magnetic resonance imaging sequences to enhance diagnostic precision in challenging scenarios. Across five diverse cases, the combined approach revealed subtle aetiologies like prepontine adhesions, fourth ventricle outlet obstruction, aqueductal stenosis and minute dural breaches - all which were undetectable with routine conventional imaging.

