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Updated: Jul 21, 2026
The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
Effect of Maternal Aerobic Exercise on Myocardial and Cerebral Ischemia/Reperfusion Injury in Offspring of
Jiaqi Cao1, Huimin Liu1, Meiling Shan1
1Department of Exercise Physiology, Beijing Sport University.
Abstract:
Hypertension-mediated organ damage (HMOD) affects vital organs such as the heart and brain, leading to adverse outcomes and posing a serious threat to human health. Maternal exercise helps promote fetal growth and development by improving the intrauterine environment, thereby reducing disease risk and enhancing offspring health. This study investigates whether maternal exercise during pregnancy can reduce the susceptibility of the offspring's heart and brain to ischemia/reperfusion (I/R) injury linked to hypertension, in order to evaluate the protective potential of maternal exercise as an early-life intervention. Pregnant normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were randomly assigned to either a sedentary (p-WKY-SED, p-SHR-SED) or exercise (p-WKY-EX, p-SHR-EX) group for the duration of their gestation. A maternal swimming exercise model was established during pregnancy. Three-month-old (3M) offspring were selected as research subjects. During this period, blood pressure was monitored, and myocardial ischemia/reperfusion injury (MI/RI) and middle cerebral artery occlusion (MCAO) surgeries were performed to induce ischemia/reperfusion (I/R) injury. Maternal exercise during pregnancy significantly reduced infarct size in both male and female offspring of hypertensive rats following MI/RI and MCAO. In the MI/RI model, infarct size was reduced by 60.9% in males and 55.9% in females. In the MCAO model, infarct size was reduced by 31.0% in males and 35.9% in females. Additionally, maternal exercise improved post-myocardial infarction (MI) cardiac function in male offspring and decreased their overall susceptibility to ischemic injury in both the heart and brain. In the context of hereditary hypertension during pregnancy, maternal aerobic exercise has been shown to confer significant protective effects on adult offspring by reducing I/R injury in the heart and brain. These findings highlight the potential of maternal exercise as an effective non-pharmacological strategy for early-life intervention to reduce susceptibility to HMOD.
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