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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Automated Spectral-Domain Versus Swept-Source OCT Angiography in Relation to Glaucoma Severity.

Massimo A Fazio1,2, Stuart K Gardiner2, K S Reynoso Moreno1

  • 1Department of Ophthalmology and Vision Science, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL.

Journal of Glaucoma
|December 8, 2025
PubMed
Summary

Higher radial peripapillary capillary density measured by OCT-A is linked to better visual field metrics in glaucoma patients. Both spectral-domain and swept-source OCT platforms showed similar diagnostic performance, supporting OCT-A

Keywords:
optical coherence tomography angiographyprimary open angle glaucomaradial peripapillary capillary densityspectral-domain OCTswept-source OCTvisual field

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Early detection and monitoring of glaucoma progression are crucial for preserving vision.
  • Optical coherence tomography angiography (OCT-A) offers detailed microvascular imaging of the optic nerve head.

Purpose of the Study:

  • To evaluate the association between OCT-A metrics, specifically radial peripapillary capillary (RPC) density, and visual field (VF) mean deviation (MD) in patients with POAG.
  • To compare the performance of spectral-domain OCT (SD-OCT) and swept-source OCT (SS-OCT) platforms in assessing this association.

Main Methods:

  • A prospective cross-sectional study involving 18 patients (28 eyes) with POAG.
  • OCT-A imaging was performed using both Topcon Maestro2 (SD-OCT) and Topcon Triton (SS-OCT).
  • RPC density was quantified from 6x6 mm² scans centered on the optic nerve head, and associations with VF parameters (MD, VFI, PSD) were analyzed using multivariable linear mixed-effects models.

Main Results:

  • Increased RPC density was independently correlated with better visual field metrics across both OCT-A platforms.
  • Each 1% increase in RPC density was associated with improved MD, VFI, and PSD values.
  • Both SD-OCT and SS-OCT systems demonstrated comparable diagnostic performance in detecting these associations.

Conclusions:

  • OCT-A-derived RPC density is a significant and independent correlate of visual field function in primary open-angle glaucoma.
  • The findings support the integration of OCT-A, including automated SD-OCT systems, into routine glaucoma assessment and screening.
  • Comparable diagnostic performance across different OCT-A technologies highlights the robustness of microvascular assessment in glaucoma.