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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Related Experiment Video

Updated: Jan 7, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Polycaprolactone/Polyethylene Glycol/Hydroxypropylmethylcellulose Blends: Tailoring Thermomechanical and Rheological

Stefania Mottola1, Sara Liparoti1, Andrea Miranda1

  • 1Department of Industrial Engineering (DIIn), University of Salerno, Via Giovanni Paolo II, 132, Fisciano, SA 84084, Italy.

ACS Applied Bio Materials
|December 8, 2025
PubMed
Summary

This study developed a pH-sensitive polymer blend for colon-targeted drug delivery. The blend, containing hydroxypropyl methylcellulose (HPMC), showed controlled release in the colon, minimizing premature drug release.

Keywords:
HPMCcolon-targeted drug deliveryinjection moldingpH-sensitive polymer blendsrelease profilesthermomechanical properties

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Polymer Chemistry

Background:

  • Colon-targeted drug delivery aims for localized administration, improving efficacy and reducing side effects.
  • Polymeric blends offer tunable properties for controlled release applications.
  • Hydroxypropyl methylcellulose (HPMC) exhibits pH-sensitive behavior, making it a candidate for targeted delivery systems.

Purpose of the Study:

  • To develop and characterize a novel polymeric blend for colon-targeted drug delivery.
  • To optimize the thermomechanical and release properties of injection-molded capsules.
  • To evaluate the pH-dependent release profile of a model drug compound.

Main Methods:

  • Formulation of polymer blends using polyethylene glycol (PEG), polycaprolactone (PCL), and varying HPMC content (22, 24, 34 wt%).
  • Characterization using rheological methods, ATR-FTIR, TGA, DSC, and SEM.
  • In vitro release studies with methylene blue under simulated gastric, intestinal, and colonic pH conditions.

Main Results:

  • The developed polymeric blends demonstrated minimal drug release at pH 2.5 and 5, indicating stability in the upper gastrointestinal tract.
  • Controlled and sustained release of methylene blue was observed at pH 6.8, characteristic of the colonic environment.
  • Higher HPMC content (34 wt%) resulted in a higher release rate, with 38% release in 12 hours and 73% in 24 hours.

Conclusions:

  • The pH-sensitive polymer blend, particularly with 34% HPMC, is a promising platform for effective colon-targeted drug delivery.
  • The study validated a model correlating drug release rate with pH and HPMC concentration.
  • The two-stage release mechanism involves initial solubilization followed by diffusion of the model compound.