Recent advances in Citri Reticulatae Pericarpium polysaccharides: Extraction, structure, bioactivity, and
Xinxin Xu1, Hui He1, Shan Jia1
1Pharmaceutical Engineering and Technology Center at Harbin University of Commerce, 150076, Harbin, China.
International Journal of Biological Macromolecules
|December 8, 2025
Summary
Citri Reticulatae Pericarpium polysaccharides (CRPPs) from aged citrus peels offer diverse health benefits, including antioxidant and immunomodulatory effects. Their bioactivities are linked to complex structures, guiding future applications in food and medicine.
Area of Science:
- Food Science
- Pharmacology
- Biochemistry
Background:
- Citri Reticulatae Pericarpium (CRP), aged citrus peel, is used medicinally and culinarily.
- Citri Reticulatae Pericarpium polysaccharides (CRPPs) are key bioactive components with nutritional and pharmacological value.
Purpose of the Study:
- To review recent advancements in CRPPs research.
- To cover extraction, characterization, bioactivities, structure-function relationships, and industrial potential of CRPPs.
Main Methods:
- Literature review synthesizing current CRPPs research.
- Analysis of studies on CRPPs extraction, purification, and structural characterization.
- Examination of research on CRPPs bioactivities and structure-function correlations.
Main Results:
- CRPPs exhibit variable monosaccharide composition and molecular weights (1.765–7940 kDa).
- CRPPs possess antioxidant, immunomodulatory, anti-inflammatory, antitumor, and gut microbiota-modulating effects.
- Bioactivities are influenced by extraction methods and structural features, such as glycosidic linkages and branching.
Conclusions:
- CRPPs are heterogeneous polysaccharides with significant bioactivities influenced by their structure.
- Structure-function relationships provide insights into CRPPs' therapeutic potential.
- This review offers a foundation for CRPPs standardization and applications in functional foods and therapeutics.
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