Carisoprodol poisoning with serotonin toxicity
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Updated: Jan 9, 2026

Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Conor Salmaan O'Flynn1, Shrey Singh2, Gim Tan2,3
1Emergency Department, The Alfred, Melbourne, Victoria, Australia c.oflynn@alfred.org.au.
Abstract:
Due to the implementation of stricter regulations in many countries, carisoprodol toxicity is an increasingly uncommon presentation to the emergency department. However, it remains a potential drug of abuse due to its low price, availability and ability to modulate GABA-A. Others have reported presentations that challenge the GABAergic mechanism of carisoprodol. Here, we present a case of serotonin syndrome with carisoprodol holding a pivotal role. This case highlights the potential serotonergic activity of carisoprodol which contradicts the agent's supposed GABAergic mechanism of action.
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