α-Selective Ring-Opening of Bicyclo[1.1.0]butanes to Access Spirocyclobutyl Lactams
Qinglong Liu1, Boyang Mu1, Haina Zhao1
1Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian 116024, P. R. China.
Abstract:
A variety of spirocyclobutyl lactams were conveniently prepared by the Brønsted acid-catalyzed α-selective ring-opening of bicyclo[1.1.0]butane (BCB) within 15 min under mild conditions without any photocatalysts, oxidants, metal catalysts, or radical initiators. This reaction involved the rapid ring-opening of BCB to generate carbocation, which further efficiently promoted intramolecular Friedel-Crafts alkylation or intramolecular spirocyclization to access diverse spirocyclobutyl lactams.
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