MoO₃-Naringin-Loaded CMC/PVA/PVP Patch: A Rapid Biofunctional Wound Dressing

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Chronic wounds present significant challenges due to prolonged healing times and high infection rates.
• Effective wound management requires advanced dressings with potent antibacterial properties to overcome infection barriers.
• Current treatments often struggle to address the complex healing environment of chronic, infected wounds.

Purpose of the Study:

• To develop and evaluate a novel polymeric wound dressing incorporating molybdenum oxide (MoO3) nanoparticles and naringin.
• To assess the antibacterial efficacy and wound healing potential of the fabricated carboxymethyl cellulose (CMC), poly(vinyl alcohol) (PVA), and polyvinylpyrrolidone (PVP) based patch.
• To investigate the physicochemical properties and in vivo performance of the advanced wound dressing.

Main Methods:

• Molybdenum oxide (MoO3) nanoparticles synthesized via wet chemical method and characterized using XRD, FTIR, and TEM.
• Antibacterial activity of MoO3 evaluated through diffusion, colony count, growth curve, and biofilm disruption assays.
• Fabricated polymer patches (CMC/PVA/PVP with and without MoO3 and naringin) assessed for biocompatibility, swelling, degradation, porosity, drug release, WVTR, MTT, and scratch assays. In vivo study conducted on Wistar rats using a full-thickness excisional wound model.

Main Results:

• Molybdenum oxide (MoO3) nanoparticles exhibited significant antibacterial activity and biofilm disruption capabilities.
• The CMC/PVA/PVP/MoO3/naringin polymer patches demonstrated favorable biocompatibility, swelling, degradation, and drug release profiles.
• In vivo studies showed the CMC/PVA/PVP/MoO3/naringin patch achieved 91% wound closure within 15 days in a rat model.

Conclusions:

• The developed polymeric patch containing molybdenum oxide (MoO3) nanoparticles and naringin is a promising candidate for treating chronic infected wounds.
• The combination of MoO3 nanoparticles and naringin in the CMC/PVA/PVP matrix enhances antibacterial properties and accelerates wound healing.
• This advanced wound dressing offers a potential solution for improving patient outcomes in chronic wound management.