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Updated: Jan 9, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Cefazolin pharmacokinetics during prolonged intermittent kidney replacement therapy
Jessica H Xu1, Sam Salman2,3,4, David Jr Morgan5
1Department of Pharmacy, Fiona Stanley Hospital, Murdoch, Australia.
Abstract:
Acute kidney injury is a frequent complication in critically ill patients and often necessitates kidney replacement therapy. Optimising antimicrobial dosing in this population is essential yet challenging owing to altered pharmacokinetics in critical illness and the wide variability of prescriptions utilised in kidney replacement therapy. This case report investigates the pharmacokinetics of cefazolin in a critically ill patient receiving prolonged intermittent kidney replacement therapy, offering insights into dosing considerations in this clinical setting.
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