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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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[Endotracheal mantle cell lymphoma: a case report]
1Shandong Public Health Clinical Center, Public Health Clinical Center Affiliated to Shandong University, Jinan 250102, China.
Summary
Mantle cell lymphoma (MCL), a rare B-cell non-Hodgkin lymphoma, can manifest in the trachea. This case highlights an unusual tracheobronchial presentation of MCL in a 60-year-old woman.
Area of Science:
- Oncology
- Pulmonology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma.
- MCL typically presents at advanced stages with extranodal involvement.
- Pulmonary and tracheobronchial manifestations of MCL are exceptionally rare.
Purpose of the Study:
- To report a rare case of tracheobronchial Mantle cell lymphoma.
- To highlight the diagnostic and management challenges of extranodal MCL in the airway.
Main Methods:
- A 60-year-old woman presented with cough and dyspnea.
- Chest CT revealed a tracheal mass causing luminal narrowing.
- Bronchoscopic biopsy and tumor resection were performed for histopathological confirmation.
Main Results:
- Histopathological examination confirmed Mantle cell lymphoma.
- The tumor was a polypoid mass arising from the left tracheal wall.
- Significant tracheal luminal narrowing was observed.
Conclusions:
- Tracheobronchial involvement is an exceedingly rare manifestation of Mantle cell lymphoma.
- Early diagnosis and intervention are crucial for managing airway compromise caused by extranodal lymphoma.
- This case underscores the importance of considering lymphoma in the differential diagnosis of unexplained tracheal masses.
