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Updated: Jul 14, 2026
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Definitions of Bronchopulmonary Dysplasia Do Not Influence Quantitative Lung Ultrasound Predictive Accuracy
Daniele De Luca1,2, Luca Bonadies3,4, Guillermo Ramos-Noguera5
1Physiopathology and Therapeutic Innovation INSERM-U999, Paris Saclay University, Paris, France, dm.deluca@icloud.com.
Introduction:
Quantitative lung ultrasound (LUS) predicts bronchopulmonary dysplasia (BPD), but variability in BPD definitions raises concerns about its predictive consistency. We hypothesized that predictive accuracy of LUS would remain stable regardless of the definition applied.
Methods:
In this prospective, multicenter cohort study, preterm infants ≤30 weeks of gestation underwent extended LUS (eLUS, adj-eLUS) aeration score at days 10, 21, and 28. BPD was assessed at 36 weeks of postmenstrual age using Jobe and Bancalari (2001), NICHD (2018), and Jensen (2019) definitions. Receiver operating characteristic (ROC) analysis compared predictive performance (areas under ROC curve [AUC]) across definitions.
Results:
Among 337 infants (mean gestational age: 27 weeks, mean birth weight: 941 g), BPD incidence ranged from 22.8 to 25.8% depending on definition. AUCs for BPD prediction ranged between 0.732 and 0.832. The mean difference (ΔAUC) between definitions was minimal (≈0.02, 95% confidence interval: 0.01-0.03) and nonsignificant at all time points.
Conclusions:
Quantitative LUS reliably predicts BPD regardless of its definition, and this support its use in early respiratory care and monitoring.
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