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Updated: Jan 9, 2026
Determining Bile Duct Density in the Mouse Liver
Published on: April 30, 2019
Diagnostic Pitfalls in Primary Biliary Cholangitis: Delta Bilirubin and Lipoprotein-X Interferences
Background:
Cholestasis in primary biliary cholangitis (PBC) induces delta bilirubin and lipoprotein-X (LpX), complicating biochemical interpretation.
Methods:
Comparative wet/dry chemistry analyses, total cholesterol (TC)/apolipoprotein B (Apo B) ratio calculation, and clinical-laboratory integration were utilized.
Results:
Delta bilirubin (87.4 µmol/L) masked true bilirubin levels, while LpX falsely elevated LDL-cholesterol (LDL-C) (23.98 mmol/L) and induced pseudohyponatremia (Na⁺: 135 → 142 mmol/L).
Conclusions:
Integrated methodologies and clinician-laboratory collaboration are essential to mitigate diagnostic pitfalls in PBC.
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