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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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A Rare Case of Cefoperazone/Sulbactam-Induced Significant Prolongation of INR

Ying Yu, Qing Wang

    Clinical Laboratory
    |December 9, 2025
    PubMed
    Abstract

    Insights

    Cefoperazone/sulbactam (CPZ/SAM) antibiotic therapy can cause extremely high INR levels. Close monitoring of coagulation function is essential to prevent adverse events during CPZ/SAM treatment.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Infectious Diseases

    Background:

    • Cefoperazone/sulbactam (CPZ/SAM) is a widely used first-line antibiotic.
    • Antibacterial agents can sometimes cause unexpected side effects.
    • Drug-induced coagulation abnormalities are a concern in clinical practice.

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