The pediatric ocular surface microbiome in pet-owning households
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View abstract on PubMed
Summary
This summary is machine-generated.Household pets alter the pediatric ocular surface microbiome (OSM). Pet exposure increases microbial diversity and activates immune pathways, potentially influencing allergy development in children.
Area Of Science
- Ophthalmology
- Microbiology
- Immunology
Background
- Pet exposure is linked to childhood allergies.
- The impact of pets on the pediatric ocular surface microbiome (OSM) is unknown.
- The OSM may mediate ocular immunity.
Purpose Of The Study
- To investigate alterations in the pediatric OSM due to household pet contact.
- To explore the relationship between pet exposure and OSM composition and function.
Main Methods
- Cross-sectional study of 347 children (5-15 years).
- 16S rRNA sequencing of conjunctival swabs.
- Bioinformatic and functional prediction analyses (QIIME2, DADA2, SILVA 138, PICRUSt2).
Main Results
- Pet-exposed children showed higher OSM alpha diversity (Shannon, Simpson, Observed indexes).
- Distinct beta diversity and enriched genera (Streptococcus, Actinomyces, Neisseria) were observed in pet-exposed children.
- Enriched NF-κB and VEGF signaling pathways in pet-exposed children; increased macrolide biosynthesis in non-exposed.
Conclusions
- Pet exposure modifies the pediatric OSM, increasing diversity and environmental taxa.
- NF-κB and VEGF pathway activation suggests a novel mechanism for pet-related immune modulation.
- Changes in OSM may influence ocular surface health and allergy susceptibility in children.
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