Engineered metallic hybrid nanozyme for advanced inflammatory disease therapy

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Inflammation presents significant therapeutic challenges due to conventional treatment limitations.
• Nanozymes, combining nanomaterials and enzymatic catalysis, show promise for inflammation therapy.
• Single-metal nanozymes have limitations in efficiency and functionality for clinical use.

Purpose of the Study:

• To review the principles, mechanisms, and therapeutic approaches for inflammation.
• To discuss nanozyme design, synthesis, and regulation strategies, focusing on metallic hybrid nanozymes.
• To evaluate the application of metallic hybrid nanozymes in treating inflammatory diseases and analyze future clinical translation.

Main Methods:

• Systematic review of fundamental principles and molecular mechanisms of inflammation.
• Comprehensive discussion on nanozyme definition, catalytic mechanisms, and rational design strategies.
• In-depth evaluation of metallic hybrid nanozymes' applications and analysis of clinical challenges.

Main Results:

• Metallic hybrid nanozymes demonstrate synergistic enhancement in catalytic performance and cascade effects.
• Advanced design strategies and combination therapies improve nanozyme efficacy for inflammation.
• Significant progress has been made in applying metallic hybrid nanozymes to various inflammatory diseases.

Conclusions:

• Metallic hybrid nanozymes represent a promising next-generation therapeutic strategy for inflammation.
• Overcoming challenges in catalytic efficiency and clinical translation is crucial for widespread adoption.
• This review provides a framework for developing advanced nanozyme therapeutics for inflammation management.