Reduced strength is associated with abnormal body composition in children with a history of intestinal failure
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Children with intestinal failure (IF) exhibit reduced muscle strength compared to norms. Strength is linked to body composition, with lower fat-free mass correlating with decreased strength, particularly in males.
Area Of Science
- Pediatric Gastroenterology
- Pediatric Endocrinology
- Pediatric Physical Therapy
Background
- Limited data exists on the relationship between body composition and muscle strength in pediatric patients with intestinal failure (IF).
- This study addresses the knowledge gap by assessing strength and its correlation with body composition in children with IF.
Purpose Of The Study
- To evaluate muscle and functional strength in children with IF against established norms.
- To investigate the association between body composition metrics and strength parameters in this cohort.
Main Methods
- Thirty-one children (aged 4-18 years) with IF were assessed for functional strength using the Bruininks-Oseretsky Test of Motor Proficiency-2 (BOT-2) and muscle strength via handgrip strength (HGS) and knee dynamometry.
- Body composition was determined using dual-energy X-ray absorptiometry (DXA).
- Statistical analyses included t-tests for group comparisons and linear regression to explore body composition-strength relationships.
Main Results
- Children with IF demonstrated significantly lower HGS, knee flexion, and extension strength compared to published norms (p < 0.05 for all).
- A substantial percentage of participants scored below average in all strength measures (80.6% for HGS, 71.0% for knee flexion, 74.2% for extension).
- Functional strength positively correlated with fat-free mass and inversely with fat mass (r² = 0.36, p = 0.002), with this relationship being stronger in males (r² = 0.62, p < 0.001).
Conclusions
- Pediatric patients with intestinal failure exhibit generalized weakness compared to healthy controls, irrespective of nutritional support method (enteral nutrition or parenteral nutrition).
- Reduced fat-free mass is a key factor associated with decreased strength in children with IF.
- The stronger association between body composition and strength in males warrants further investigation into underlying physiological mechanisms.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Strictureplasty
Proctocolectomy or total colectomy with ileostomy
Restorative proctocolectomy with Ileal pouch-anal anastomosis