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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Advances in gold-catalyzed asymmetric alkyne functionalization
Kewei Chen1, Minghan Yao2, Xinfang Xu1,3
1School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China. xuxinfang@zstu.edu.cn.
Gold catalysis enables enantioselective alkyne transformations, advancing synthetic chemistry. This review details key intermediates and chiral induction patterns for developing new asymmetric methods.
Area of Science:
- Organic Chemistry
- Catalysis
- Asymmetric Synthesis
Background:
- Alkynes are crucial building blocks in synthesis.
- Gold catalysis has significantly advanced alkyne transformations.
- Enantioselective synthesis of non-activated alkynes remains challenging.
Purpose of the Study:
- To comprehensively review advances in gold-catalyzed enantioselective alkyne transformations.
- To organize progress based on key gold intermediates and chirality induction.
- To inspire innovative synthetic methodologies through understanding reaction mechanisms.
Main Methods:
- Review of literature on gold-catalyzed alkyne transformations.
- Classification of reactions by gold intermediates (carbene/carbenoid, Csp2-Au, Csp3-Au).
- Analysis of reaction patterns, chiral ligands, and catalytic methodologies.
Main Results:
- Significant progress in asymmetric alkyne transformations using gold complexes.
- Detailed insights into gold carbene/carbenoid, Csp2-Au, and Csp3-Au species.
- Understanding of chirality induction patterns in gold-catalyzed reactions.
Conclusions:
- Gold catalysis is powerful for enantioselective alkyne synthesis.
- Understanding key intermediates is vital for rational reaction design.
- This review provides a foundation for future asymmetric alkyne transformations.
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