A Remotely Actuated Multifunctional Nitinol-PMMA Smart Biocomposite: Microcellular Foaming, Shape Morphing, and...

Area of Science:

• Biomaterials Science
• Materials Engineering
• Medical Device Technology

Background:

• Developing smart biomaterials for in vivo applications is crucial for therapeutic medicine.
• Existing materials often lack multifunctionality and remote actuation capabilities.
• Advanced composites are needed to integrate complex functions for minimally invasive medical devices.

Purpose of the Study:

• To fabricate a remotely actuated, multifunctional smart biocomposite using Nitinol and PMMA.
• To investigate the composite's capabilities for shape morphing, microcellular foaming, and controlled drug release.
• To evaluate the potential of the Nitinol-PMMA composite for applications like vascular clamping.

Main Methods:

• Fabrication of a Nitinol-PMMA composite.
• Application of a noncontact electromagnetic field to induce shape morphing and microcellular foaming.
• In vitro testing for vascular clamping potential and cytocompatibility with NIH 3T3 fibroblasts.
• Drug release kinetic analysis using the Korsmeyer-Peppas model.

Main Results:

• The Nitinol-PMMA composite demonstrated simultaneous shape morphing and microcellular foaming.
• Impact strength was enhanced by 143% due to microcellular foaming.
• Controlled release of sodium benzoate (NaBz) was achieved, governed by a quasi-Fickian mechanism.
• The composite showed excellent cytocompatibility and potential for vascular clamping.

Conclusions:

• The fabricated Nitinol-PMMA biocomposite successfully integrates shape morphing, microcellular foaming, and controlled drug delivery.
• This remotely actuated system offers a promising approach for developing advanced, minimally invasive medical devices.
• The material's properties suggest significant potential for customized therapies and improved medical interventions.