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Updated: Jan 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-Light-Induced Trifluoromethyloximation of Alkenes with Sodium Nitrite as Oxime Source
Renqin Zhan1, Xiaoting Zou1, Xinlong Han1
1The State Key Laboratory of Natural Product Chemistry, and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Abstract:
A visible-light-induced, transition-metal- and photosensitizer-free three-component trifluoromethyloximation of alkenes is described herein. This established visible-light-driven difunctionalization process enables the straightforward and productive preparation of a diverse array of α-CF3 ketoximes with high regioselectivity. The strategy employs commercially abundant and robust alkenes as starting materials, economical CF3SO2Cl as the trifluoromethylating agent, and NaNO2 as the nitrosyl source, operating without transition-metal catalysts or external photosensitizers. This approach demonstrates broad functional group compatibility, high selectivity, mild reaction conditions, and excellent practicality.
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