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Updated: Jan 9, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

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Published on: February 1, 2019

Engineered Multilamellar Cationic Liposomes with High Loading Efficiency and Stability for Enhanced Transdermal

Wanping Zhang^1,2, Zhe Li², Xun Bu²

¹Collaborative Innovation Center of Fragrance Flavour and Cosmetics, School of Perfume and aromtechnology, Shanghai Institute of Technology, Shanghai 201418, China.

Langmuir : the ACS Journal of Surfaces and Colloids

|December 9, 2025

Summary

Multilamellar cationic liposomes (MCLs) offer a stable, non-irritating transdermal drug delivery solution. These novel liposomes demonstrate enhanced permeation and high encapsulation efficiency for therapeutics like retinol.

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Last Updated: Jan 9, 2026

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

Materials Science
Biotechnology
Pharmaceutics

Background:

Cationic liposomes (CLs) are promising drug carriers due to biodegradability and permeation.
Challenges with CLs include irritation, stability, and effective transdermal delivery.

Purpose of the Study:

To develop stable, non-irritating multilamellar cationic liposomes (MCLs) for enhanced transdermal delivery.
To investigate the molecular assembly and characterize the properties of the developed MCLs.

Main Methods:

MCLs were formulated using soy lecithin, cholesterol, and a cationic surfactant in a polyol solvent.
Molecular assembly was studied using isothermal titration calorimetry (ITC) and 2D-ROESY.
Safety and efficacy were assessed via chick chorioallantoic membrane assays and porcine ear skin permeation studies.

Main Results:

MCLs exhibited an onion-like structure, ~300 nm size, and high zeta potentials (40-60 mV).
Chick chorioallantoic membrane assays showed minimal bleeding (ESI < 12), indicating non-irritancy.
Retinol-loaded MCLs achieved 80.29% encapsulation and demonstrated significantly higher cumulative release in porcine skin.

Conclusions:

The developed MCLs provide a stable and efficient platform for transdermal drug delivery.
This formulation overcomes key limitations of traditional CLs, offering improved safety and efficacy.
MCLs represent a strategic advancement for next-generation transdermal systems.