Related Experiment Video
Updated: Jan 7, 2026
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Association between vertebral fracture risk and bone mineral density in patients with acromegaly
Shuaiming Chen1, Min Liu1, Huiwen Tan1
1Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Purpose:
To investigate the prevalence and risk factors of vertebral fractures (VFs) and to compare bone mineral density (BMD) assessments by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) in patients with acromegaly.
Methods:
This cross-sectional study included 149 patients with acromegaly. Clinical, biochemical, and imaging data were collected, and logistic regression analyses were performed to identify VF risk factors.
Results:
VFs were detected in 39.6% of patients and were associated with older age, longer disease duration, higher body mass index(BMI), elevated IGF-1 levels, and lower serum phosphorus. QCT-derived volumetric BMD (vBMD) was significantly lower in patients with VFs, whereas DXA-based lumbar areal BMD (aBMD) did not differ between groups. Elevated IGF-1 (%ULN) and reduced vBMD were identified as independent risk factors for VFs.
Conclusion:
Vertebral fractures are common in acromegaly. In one of the largest Chinese acromegaly cohorts to date, QCT demonstrated superior discrimination of VF risk compared with DXA, supporting its potential complementary role in skeletal fragility assessment in acromegaly.
More Related Videos
04:19Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
Published on: November 8, 2024
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
