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Role of Family Dynamics in Shaping Coping Strategies Among Children with Transfusion-Dependent Thalassemia

Muditadeep Kaur1, Palak Upadhyay2, Gursabeen Kaur3

  • 1Department of Clinical Psychology, Lovely Professional University, Phagwara, Punjab, India.

Indian Pediatrics
|December 9, 2025
PubMed

Insights

Children with transfusion-dependent thalassemia (TDT) utilize adaptive coping strategies but experience significant challenges. Their parents face compromised family functioning and reduced quality of life, necessitating targeted psychosocial support.

Area of Science:

  • Pediatric Hematology
  • Psychosocial Oncology
  • Family Studies

Background:

  • Transfusion-dependent thalassemia (TDT) imposes substantial physical, emotional, and social burdens on affected children and their families.
  • Understanding the coping mechanisms of children with TDT and the impact on parental well-being is crucial for developing effective support interventions.

Purpose of the Study:

  • To compare the coping strategies of children with TDT against healthy controls.
  • To assess and compare the impact of TDT on parental functioning and family quality of life.

Main Methods:

  • A case-control study involving 75 children with TDT (aged 8-16) and 150 age-matched healthy controls.
  • Psychological assessments using the PedsQL™ Family Impact Module and KidCOPE.
  • Statistical comparison using the Mann-Whitney U test.

Main Results:

  • Children with TDT demonstrated less self-criticism, higher problem-solving efficacy, and greater use of social support compared to controls.
  • Parents of children with TDT reported significantly poorer overall family functioning and lower quality of life (P<0.001).

Conclusions:

  • Despite employing adaptive coping mechanisms, children with TDT experience significant psychosocial challenges.
  • The findings underscore the critical need for integrated psychosocial support systems that address the well-being of both children with TDT and their caregivers.
Abstract

Keywords:
Coping strategiesFamily functioningMental healthQuality of lifeTransfusion-dependent thalassemia

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