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Overview of ocular toxicities associated with breast cancer therapies

Megan R Greenberg1, Alexandra Noveihed1, Mridula George2

  • 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Breast Cancer Research and Treatment
|December 9, 2025
PubMed
Abstract

Insights

Novel targeted therapies improve breast cancer survival but can cause ocular toxicities. Increased provider awareness of these eye side effects is crucial for early detection and management.

Area of Science:

  • Oncology
  • Ophthalmology

Background:

  • Breast cancer is a leading global malignancy in women.
  • Novel targeted therapies have improved survival rates.
  • Ocular toxicities are underrecognized side effects of these treatments.

Purpose of the Study:

  • To review ocular toxicities associated with novel targeted breast cancer therapies.
  • To raise provider awareness of potential eye-related adverse effects.

Main Methods:

  • Literature review on ocular toxicities.
  • Analysis of prevalence, characteristics, and management strategies.

Main Results:

  • Identified major ocular toxicities linked to targeted breast cancer therapies.
  • Summarized current clinical management strategies.

Conclusions:

  • Ocular adverse effects are an important consideration in targeted breast cancer therapy.
  • Prompt recognition and ophthalmologist referral are key for management.
Keywords:
Breast cancerEye toxicityOcular toxicitiesTreatment-related adverse events

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