The effects of acute and chronic exercise on lipocalin-2 in middle-aged and older adults: a randomized control trial
Carlie Bauer1,2, Marc Sim3,4, Cassandra Smith3,4
1Institute for Health and Sport, Victoria University, Melbourne 3011, Australia.
Objective:
Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardio-metabolic disease risk, and poor physical function. Exercise is known to improve these factors, but whether LCN2 is modifiable by exercise is not clear. We examined the effect of acute and chronic exercise on LCN2 levels and whether this relates to glucose regulation, body composition, and physical function.
Design And Methods:
Thirty-three middle-aged and older adults (45-84 years, median body mass index 26.21 kg/m2) completed an acute high-intensity interval exercise session (HIIE). Participants were randomized to 4 weeks of high-intensity interval training (HIIT) or control. Lipocalin-2, insulin, glucose, and homeostatic model assessment for insulin resistance (HOMA-IR) were analysed in serum at baseline and immediately, 1 and 3 h post-HIIE, and post-4 weeks of HIIT. Urinary LCN2 was assessed pre and post 4 weeks of HIIT.
Results:
A main effect for time for serum LCN2, insulin, glucose, and HOMA-IR was detected after acute-HIIE (P < .001). Circulating serum LCN2 levels increased significantly immediately post-HIIE compared to baseline (P < .001) and returned to levels similar to baseline by 60 and 180 min post-HIIE. Four weeks of HIIT improved VO2peak, yet had no significant effect on LCN2 levels or physical function.
Conclusions:
Acute-HIIE, but not 4 weeks of HIIT, transiently increased circulating LCN2 and improved insulin sensitivity in middle-aged and older adults. It remains unclear if LCN2 is modifiable by chronic exercise training longer than 4 weeks or in people with poor glycaemic control.
Clinical Trial Registration:
Australia New Zealand Clinical Trials Registry: ACTRN12622000337774.
More Related Videos
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...