Receptor-targeted metal-organic frameworks: Recent progress in synthesis, modifications, and applications in targeted...

Metal-organic frameworks (MOFs) have emerged as pivotal materials in contemporary scientific research, offering vast potential for the development of portable and sophisticated systems. This has opened new avenues for exploration across various fields and enabled a broad spectrum of novel applications. Over the past decade, MOFs have rapidly evolved in drug delivery systems (DDS), showcasing significant advancements in the creation of novel targeted platforms. Notably, receptor-targeted MOFs have introduced innovative architectures with adaptable features, particularly in biologically relevant scaffolds, thereby suggesting alternatives for cancer therapy. This review delves into recent developments in receptor-targeted MOFs, focusing on their synthesis, chemical modification, and applications in targeted anticancer drug delivery, highlighting their potential to drive future innovations in biomedical fields.