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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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Multiparametric Saturation Transfer MR Fingerprinting Using Rosette-Accelerated Readout.

Sultan Z Mahmud1, Hye-Young Heo1

  • 1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

NMR in Biomedicine
|December 9, 2025
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Summary
This summary is machine-generated.

This study introduces a fast, multiparametric MRI method to simultaneously measure multiple tissue properties like water content and myelin. This novel technique offers efficient brain imaging for potential disease diagnosis.

Keywords:
CESTMR fingerprintingMTCMWFSWI

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Area of Science:

  • Biomedical Imaging
  • Quantitative MRI
  • Magnetic Resonance Fingerprinting

Background:

  • Conventional quantitative MRI methods measure tissue parameters individually, which is inefficient for clinical applications.
  • Magnetic Resonance Fingerprinting (MRF) enables simultaneous acquisition of multiple tissue properties, improving efficiency.

Purpose of the Study:

  • To develop and validate a novel, multiparametric MRF framework for simultaneous quantitative measurement of bulk water, magnetization transfer (MT), myelin water fraction (MWF), B0 inhomogeneity (ΔB0), and susceptibility-weighted imaging (SWI) contrast.
  • To integrate chemical exchange saturation transfer (CEST) imaging contrast within the MRF framework.

Main Methods:

  • Developed a motion-robust, rosette-accelerated MRF sequence incorporating RF saturation and T2-preparation modules.
  • Optimized MRF acquisition parameters and acquired data from healthy volunteers at 3T.
  • Estimated quantitative tissue parameters from MRF signal evolutions and compared them with conventional standalone sequences.

Main Results:

  • The multiparametric rosette-MRF technique achieved excellent agreement with reference parameters for bulk water, MT, MWF, SWI, and ΔB0.
  • Higher MWF and semisolid macromolecular pool size ratio were observed in white matter compared to gray matter.
  • Synthesized multimolecular contrast images (MTC, APT, rNOE, CEST) using Bloch equations and MRF-derived parameters.

Conclusions:

  • The developed rosette-accelerated, multiparametric MRF technique enables efficient, simultaneous measurement of diverse MRI biomarkers.
  • This approach holds potential for valuable insights into disease pathology and clinical evaluation of MRI biomarkers.
  • Synthetic MRI analysis combined with MRF offers a powerful tool for rapid, comprehensive brain imaging.