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Related Experiment Video

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Cardiovascular risk following transient vision loss.

Tasha Miller1, Jim Shenchu Xie2, Aljeena Rahat Qureshi1

  • 1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

The British Journal of Ophthalmology
|December 9, 2025
PubMed
Summary

Transient vision loss (TVL) significantly elevates short- and long-term cardiovascular risks, including stroke and major adverse cardiovascular events (MACE). Prompt systemic evaluation and ongoing monitoring are crucial for affected individuals.

Keywords:
TriNetXmajor adverse cardiovascular eventsstroketransient vision loss

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Area of Science:

  • Cardiology
  • Neurology
  • Ophthalmology

Background:

  • Transient vision loss (TVL) is a concerning symptom requiring investigation into its potential systemic implications.
  • Understanding the cardiovascular risk associated with TVL is essential for patient management.

Purpose of the Study:

  • To assess the short- and long-term cardiovascular risk following a first diagnosis of transient vision loss (TVL).
  • To compare cardiovascular outcomes in TVL patients with a matched control group.

Main Methods:

  • Retrospective analysis of 37,750 patients with incident TVL, propensity score-matched to controls with dry eye syndrome.
  • Utilized the TriNetX research network to evaluate outcomes including major adverse cardiovascular events (MACE), stroke, myocardial infarction (MI), and all-cause mortality.
  • Employed Cox proportional hazards models to estimate hazard ratios (HRs) over a 10-year period, with subgroup analyses for early event-free patients.

Main Results:

  • TVL diagnosis was associated with a >21-fold increased stroke risk and nearly 10-fold increased MACE risk within 14 days.
  • Short-term risks for arrhythmia, MI, and hospitalization were also significantly elevated post-TVL.
  • Elevated long-term risks for MACE, stroke, arrhythmia, and hospitalization persisted up to 10 years in patients event-free at 90 days or 1 year.

Conclusions:

  • Transient vision loss (TVL) is linked to substantial short- and long-term cardiovascular risks.
  • The findings underscore the need for immediate systemic evaluation and sustained monitoring in patients experiencing TVL.
  • Prompt medical attention following TVL can mitigate potential severe cardiovascular outcomes.