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Cardiovascular risk following transient vision loss
Tasha Miller1, Jim Shenchu Xie2, Aljeena Rahat Qureshi1
1Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
The British Journal of Ophthalmology
|December 9, 2025
Summary
Transient vision loss (TVL) significantly elevates short- and long-term cardiovascular risks, including stroke and major adverse cardiovascular events (MACE). Prompt systemic evaluation and ongoing monitoring are crucial for affected individuals.
Area of Science:
- Cardiology
- Neurology
- Ophthalmology
Background:
- Transient vision loss (TVL) is a concerning symptom requiring investigation into its potential systemic implications.
- Understanding the cardiovascular risk associated with TVL is essential for patient management.
Purpose of the Study:
- To assess the short- and long-term cardiovascular risk following a first diagnosis of transient vision loss (TVL).
- To compare cardiovascular outcomes in TVL patients with a matched control group.
Main Methods:
- Retrospective analysis of 37,750 patients with incident TVL, propensity score-matched to controls with dry eye syndrome.
- Utilized the TriNetX research network to evaluate outcomes including major adverse cardiovascular events (MACE), stroke, myocardial infarction (MI), and all-cause mortality.
- Employed Cox proportional hazards models to estimate hazard ratios (HRs) over a 10-year period, with subgroup analyses for early event-free patients.
Main Results:
- TVL diagnosis was associated with a >21-fold increased stroke risk and nearly 10-fold increased MACE risk within 14 days.
- Short-term risks for arrhythmia, MI, and hospitalization were also significantly elevated post-TVL.
- Elevated long-term risks for MACE, stroke, arrhythmia, and hospitalization persisted up to 10 years in patients event-free at 90 days or 1 year.
Conclusions:
- Transient vision loss (TVL) is linked to substantial short- and long-term cardiovascular risks.
- The findings underscore the need for immediate systemic evaluation and sustained monitoring in patients experiencing TVL.
- Prompt medical attention following TVL can mitigate potential severe cardiovascular outcomes.
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