Anti-Aggregation System for the Enhanced Transdermal Delivery of Cell Membrane-Coated Nanoparticles.

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Dermatology

Background:

• Cell membrane-coated nanoparticles (CMNPs) show promise for in vivo disease treatment due to high targeting efficiency and biocompatibility.
• Current noninvasive delivery methods for CMNPs struggle with coating stability and distribution efficiency.

Purpose of the Study:

• To develop a novel platform for the transdermal delivery of CMNPs.
• To overcome limitations in stability and distribution efficiency for noninvasive CMNP therapeutics.

Main Methods:

• Development of an antiaggregation transdermal delivery tool (AATDT) using beeswax and hyaluronic acid.
• Evaluation of AATDT's effect on CMNP surface energy, aggregation, and skin permeation.
• Assessment of CMNP distribution depth and systemic toxicity after transdermal delivery.

Main Results:

• The AATDT effectively reduced CMNP surface energy, preventing aggregation.
• Enhanced skin hydration facilitated CMNP permeation to depths over 500 μm.
• Transdermal delivery achieved significant CMNP distribution without observable systemic toxicity.

Conclusions:

• The AATDT provides a stable and efficient noninvasive strategy for transdermal delivery of CMNPs.
• This platform offers a clinically translatable approach for enhancing CMNP therapeutic applications.
• The developed system addresses key challenges in noninvasive nanoparticle delivery.