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Updated: Jan 9, 2026

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
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RAB25 modulates pit cell commitment by coordinating transforming growth factor-alpha secretion from gastric

Haengdueng Jeong1,2,3, Yura Lee1, Chanyang Uhm1

  • 1Department of Biomedical Sciences, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Cell Death & Disease
|December 9, 2025
PubMed
Summary

Rab25 loss in the stomach increases transforming growth factor-alpha (TGFA), promoting EGFR signaling and gastric lesions. Restoring TGFA levels or blocking it ameliorates these effects, highlighting Rab25

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