Risk factors for pulmonary function alterations in children with metabolic dysfunction-associated fatty liver disease
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View abstract on PubMed
Summary
This summary is machine-generated.Children with metabolic dysfunction-associated fatty liver disease (MAFLD) show impaired small airway function, independent of BMI. Insulin resistance and IL-1β are key risk factors for this lung dysfunction.
Area Of Science
- Pediatric Pulmonology
- Hepatology
- Metabolic Disorders
Background
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly diagnosed in children.
- Pulmonary function abnormalities in pediatric MAFLD are suspected but not well-characterized, particularly their independence from BMI.
- Risk factors for impaired lung function in this population require further elucidation.
Purpose Of The Study
- To investigate pulmonary function parameters in overweight/obese children with MAFLD compared to controls.
- To determine if lung function abnormalities are independent of body mass index (BMI).
- To identify risk factors, including metabolic and inflammatory markers, associated with abnormal pulmonary function in pediatric MAFLD.
Main Methods
- Comparative study of 40 overweight/obese children with MAFLD and 30 controls.
- Assessment of pulmonary function parameters (FVC, PEF, FEV1/FVC, FEF50, FEF75, MMEF) and anthropometrics.
- Analysis of liver function, lipid/glucose metabolism (HOMA-IR), and cytokine levels (IL-1β).
- Multivariable regression analysis to identify risk factors for abnormal pulmonary function.
Main Results
- No significant difference in BMI between MAFLD and control groups.
- Children with MAFLD exhibited higher FVC but lower PEF, FEV1/FVC, FEF50, FEF75, and MMEF.
- Insulin resistance (HOMA-IR) was inversely associated with FEF25, FEF50, and FEF75.
- Elevated IL-1β levels were negatively correlated with MMEF and FEF50.
Conclusions
- Pediatric MAFLD is associated with altered lung function, including impaired small airway function, independent of BMI.
- HOMA-IR and elevated IL-1β are significant risk factors contributing to abnormal small airway function in children with MAFLD.
- These findings highlight the systemic impact of MAFLD on respiratory health in children and underscore the need for integrated management.
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