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HDAC2-mediated chromatin remodeling drives hepatocellular carcinoma progression: an integrative analysis of

Shiyang Yin1, Xuancheng Zhou1, Lai Jiang1

  • 1Clinical Medical College, Southwest Medical University, Luzhou, 646000, China.

Journal of Translational Medicine
|December 9, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Chromatin remodelingComputational pathologyHepatocellular carcinomaHistone deacetylase 2Multi-omicsPrognostic modelSingle-cell transcriptomicsSpatial transcriptomics

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Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...