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Clinical Effectiveness of Ocimum basilicum Mouthwash as an Adjunct to Toothbrushing in Managing Patients With
Atrey J Pai Khot1,2, Anu Sara Varghese1, Anil V Ankola1
1Department of Public Health Dentistry, KLE Vishwanath Katti Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
Background:
Among the several antiseptic mouthwashes, chlorhexidine is considered the gold standard owing to its better antigingivitis and antiplaque benefits; yet, its usage is restricted due to noteworthy adverse effects leading to an increasing demand for herbal alternatives that are natural, and have fewer side effects. The objective of the study was to assess the short-term effect of 30% Ocimum basilicum (OB) and 0.2% Chlorhexidine (CHX) mouthwashes on gingival health and plaque control when used as an adjunct to toothbrushing in patients with plaque-induced gingivitis.
Methodology:
A parallel-arm, double-blinded, randomised controlled trial was conducted among 70 adult patients. The participants were randomly assigned to two groups: 30% OB mouthwash group (n = 35) and 0.2% CHX mouthwash group (n = 35) by the lottery method. Both participants and the examiner were blinded throughout the study period. The gingival index, plaque index and adverse effects were recorded at baseline, 7th and 21st day. Unpaired t-tests and repeated measures ANOVA tests were utilised to compare the mean gingival and plaque scores between the groups.
Results:
Both groups exhibited a gradual and significant reduction in both gingival and plaque scores from baseline to days 7 and 21 (p < 0.001). However, the CHX group showed a significant reduction in GI (0.48 ± 0.18) and PI (0.59 ± 0.14) from baseline to 21 days, respectively when compared to the OB group GI (0.72 ± 0.22) and PI (0.77 ± 0.19).
Conclusion:
OB mouthwash demonstrated non-inferiority in anti-gingivitis and anti-plaque properties compared to CHX mouthwash, suggesting its potential suitability as an alternative to CHX when used alongside mechanical plaque control measures in the management of gingivitis.
Trial Registration:
ClinicalTrials.gov identifier: CTRI/2022/07/044104.
