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Updated: Jan 9, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photoinduced Cobalt-Catalyzed Reductive Coupling of Aryl Bromides and 1,4-Dihydropyridines
Rui-Rui Zhao1, Qian Yang1, Wei Xiong1
1Hubei Engineering Research Center for Photochemistry and Technology, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, 430079, China.
Abstract:
The construction of C(sp2)─C(sp3) bond represents a fundamental yet challenging transformation in organic synthesis. Here, we reported a photoinduced cobalt-catalyzed reductive coupling reaction that efficiently constructs C(sp2)─C(sp3) bond between aryl bromides and 1,4-dihydropyridines. This protocol exhibits good functional group compatibility and broad substrate scope (31 examples, up to 93% yield) under mild reaction conditions. Mechanistic studies reveal that the alkylzinc reagents may be generated via photoinduced single-electron reduction, expanding the synthetic box for organozinc compound preparation.
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