Association of serological markers and interstitial lung disease in patients with suspected myositis

This study aims to investigate the relationship between serological markers and interstitial lung disease (ILD) in suspected myositis patients with positive myositis antibodies. We collected samples from 56 patients with suspected myositis and positive myositis antibodies before treatment. Serological markers, clinical symptoms, and diagnoses were analyzed. Among the 56 patients, 33.93% developed ILD and 66.07% did not. Univariate analysis revealed that some factors were significantly different between the no ILD and ILD groups. Multiple logistic regression analysis showed that albumin (ALB), idiopathic inflammatory myopathies (IIM), and tumor markers were independent factors influencing ILD. A receiver operating characteristic curve was constructed. Spearman's correlation analysis revealed that ALB, IIM, and tumor markers were strongly correlated with ILD. In patients with suspected immune mediated myositis and positive myositis antibodies, factors including ALB, IIM, and tumor markers are related to ILD. These findings provide a clinical basis for the prediction and early diagnosis of ILD.