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Updated: Jan 9, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Advances on gradient scaffolds for osteochondral tissue engineering.

Joaquim M Oliveira^1,2, Viviana P Ribeiro^1,2, Rui L Reis^1,2

¹3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark-Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, Guimarães 4805-017, Portugal.

Progress in Biomedical Engineering (Bristol, England)

|December 10, 2025

Summary

This summary is machine-generated.

Gradient scaffolds offer promising solutions for osteochondral tissue engineering (OCTE) by addressing the complex biological challenges of osteochondral defects. This review focuses on gradient scaffold strategies for OCTE and their clinical translation.

Area of Science:

Biomaterials Science
Regenerative Medicine

Keywords:

biomaterials gradients osteochondral scaffolds stem cells tissue engineering

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Last Updated: Jan 9, 2026

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Tissue Engineering

Background:

The osteochondral (OC) tissue, comprising articular cartilage and subchondral bone, presents unique hierarchical and transitional complexities.
Osteochondral diseases like osteoarthritis and traumatic injuries pose significant regenerative challenges due to their impact on cartilage, calcified cartilage, and bone.
Current regenerative approaches struggle to fully replicate the intricate biochemical, mechanical, structural, and metabolic gradients of native OC tissue.