Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Glycosylation01:25

Protein Glycosylation

9.2K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting Simultaneous Liver and Kidney Transplantation from Donors After Circulatory Death in the Era of Machine Perfusion Technologies: A US Nationwide Analysis of 10,687 Cases.

Annals of surgery·2026
Same author

Endovascular repair of traumatic innominate artery injury: case report.

Journal of surgical case reports·2026
Same author

Cnidarian-algal partnerships structure bacterial communities during strobilation in <i>Cassiopea xamachana</i>.

ISME communications·2026
Same author

Metabolic Remodeling of the Parkinson's Disease Frontal Cortex Revealed by LC-MS/MS Metabolomics.

Biomolecules·2026
Same author

High-resolution LC-MS/MS analysis of brain N-glycans reveals composition-specific changes in Parkinson's disease.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2026
Same author

Qualitative Characterization of Neu5Gc-Containing N-Glycans in Commercial Cheddar Cheese Products Using Nano-UHPLC-ESI-MS/MS-A Pilot Study.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jan 9, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.0K

Advances in MS-based glycomics for biomedical research.

Joy Solomon1, Akeem Sanni1, Waziha Purba1

  • 1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, TX 79409-1061, USA. joy.solomon@ttu.edu.

Analytical Methods : Advancing Methods and Applications
|December 10, 2025
PubMed
Summary

Glycosylation analysis using mass spectrometry (MS) is advancing rapidly. New MS techniques and computational tools improve glycan structure prediction and data interpretation for disease biomarker discovery.

More Related Videos

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.7K
Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.0K
Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.7K
Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.1K

Area of Science:

  • Biochemistry and Molecular Biology
  • Analytical Chemistry
  • Bioinformatics

Background:

  • Glycosylation, a key post-translational modification, impacts protein function and is implicated in diseases like cancer.
  • Aberrant glycosylation patterns serve as potential biomarkers for disease diagnosis and therapeutic targets.
  • Mass spectrometry (MS) offers high sensitivity and specificity for analyzing complex glycan structures.

Purpose of the Study:

  • To review recent advancements in mass spectrometry (MS)-based glycomics.
  • To highlight improved techniques for glycan analysis, quantification, and interpretation.
  • To explore the integration of computational tools for glycomics research.

Main Methods:

  • Advanced sample preparation techniques for glycomics.
  • Novel ionization and fragmentation strategies in mass spectrometry.
  • Quantitative methods including stable isotope labeling, isobaric tagging, and label-free approaches.

Main Results:

  • Significant progress in MS-based glycomics enabling detailed glycan analysis.
  • Development of robust quantitative strategies for precise glycan measurement.
  • Integration of bioinformatics, AI, and machine learning enhances glycan structure prediction and data interpretation.

Conclusions:

  • MS-based glycomics is a powerful approach for understanding glycosylation's role in health and disease.
  • Technological and computational advances are accelerating biomarker discovery and therapeutic development.
  • The integration of AI and machine learning promises to revolutionize glycomics data analysis.