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Peroxisomes

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

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Related Experiment Video

Updated: May 7, 2026

Protocol to Create Chronic Wounds in Diabetic Mice

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Lattice-Reconstructed Ru-Clusters on FeOOH-Based Self-Adaptive Artificial Peroxisome with Programmed ROS Regulation

Heng Yang¹, Xiaoke Jia¹, Ting Wang¹

¹College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, China.

Advanced Materials (Deerfield Beach, Fla.)

|December 10, 2025

Summary

This summary is machine-generated.

This study introduces an artificial peroxisome (LR-RuC@FeOOH) that uses pH-controlled reactive oxygen species (ROS) to treat chronic wounds. It effectively clears bacteria, reduces inflammation, and promotes healing in diabetic foot ulcers.

Keywords:

artificial enzymes bioinspired materials chronic refractory wounds drug‐resistant bacteria reactive oxygen species

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Published on: August 21, 2021

Area of Science:

Biomaterials Science
Nanotechnology
Wound Healing

Background:

Chronic refractory wounds pose significant clinical challenges due to bacterial colonization, inflammation, and poor angiogenesis.
Current treatments struggle to address these interconnected issues simultaneously, highlighting the need for integrated therapeutic strategies.

Purpose of the Study:

To design a self-adaptive artificial peroxisome (LR-RuC@FeOOH) for treating infectious and inflammatory chronic wounds.
To achieve programmed reactive oxygen species (ROS) regulation for sequential therapeutic effects.

Main Methods:

Fabrication of lattice-reconstructed Ru-clusters on FeOOH-based artificial peroxisomes.
Utilizing density functional theory (DFT) to investigate pH-switchable ROS-catalytic behaviors.
In vivo evaluation using a diabetic foot ulcer model.

Main Results:

LR-RuC@FeOOH demonstrated pH-switchable ROS generation, disrupting bacteria in acidic conditions and scavenging ROS in neutral conditions.
In vivo studies showed significant bacterial clearance, reduced inflammation, enhanced neovascularization, and accelerated wound closure.
The material facilitated a staged therapeutic progression from infection control to inflammation resolution.

Conclusions:

LR-RuC@FeOOH acts as an artificial peroxisome with stage-specific therapeutic capabilities.
This approach shows promising translational potential for treating refractory diabetic wounds and other infection-related pathologies.