Rhabdomyolysis
Kavita M Grover1,2, Naganand Sripathi1,2
1Department of Neurology, Henry Ford Health, Detroit, Michigan, USA.
Muscle & Nerve
|December 10, 2025
Summary
Rhabdomyolysis, a condition of severe muscle injury indicated by high creatine kinase levels, can stem from trauma, medications, or various disorders. Prompt identification of triggers and appropriate treatment, including fluid therapy and metabolic correction, are crucial for managing this condition.
Area of Science:
- Biochemistry
- Pathology
- Internal Medicine
Background:
- Rhabdomyolysis is defined by significant muscle damage and elevated creatine kinase levels.
- Muscle injury can arise from diverse causes including trauma, medications, toxins, and underlying health conditions.
- A thorough patient history is essential for pinpointing the root cause of rhabdomyolysis.
Purpose of the Study:
- To review the etiology, diagnosis, and management of rhabdomyolysis.
- To emphasize the importance of identifying and removing inciting factors.
- To outline current treatment strategies for rhabdomyolysis and its complications.
Main Methods:
- Literature review of rhabdomyolysis causes and treatments.
- Analysis of diagnostic approaches including historical review.
- Evaluation of therapeutic interventions such as fluid resuscitation and metabolic correction.
Main Results:
- Rhabdomyolysis etiology is multifactorial, including trauma, drugs, and genetic predispositions.
- Early identification and removal of causative agents are critical.
- Aggressive fluid therapy, metabolic correction, and renal support are key treatment components.
Conclusions:
- Prompt diagnosis and management are vital for improving outcomes in rhabdomyolysis.
- Addressing the underlying cause and initiating supportive care can prevent severe complications.
- Rhabdomyolysis requires a comprehensive approach involving trigger identification and targeted medical interventions.
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