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Related Concept Videos

Exon Recombination02:32

Exon Recombination

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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Viral Recombination00:57

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Retroviruses02:33

Retroviruses

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Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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Related Experiment Video

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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DDX17 and viral infection.

Yuting Cheng1, Ruohan Wang2, Anping Wang1

  • 1Engineering Technology Research Center for Modern Animal Science and Novel Veterinary Pharmaceutic Development, Jiangsu Key Laboratory of Veterinary Bio-Pharmaceutical High Technology Research, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, China.

Virulence
|December 10, 2025
PubMed
Summary

DEAD-box RNA helicase 17 (DDX17) plays a dual role in viral infections, either promoting or inhibiting viral replication. This protein is a potential antiviral therapeutic target.

Keywords:
DDX17RNA helicaseantiviral targetreplicationviral infection

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Area of Science:

  • Molecular Biology
  • Virology
  • Immunology

Background:

  • DEAD-box RNA helicase 17 (DDX17) is a host cell protein involved in RNA metabolism.
  • DDX17 participates in cellular processes crucial during viral infections, including RNA splicing and transcriptional regulation.

Purpose of the Study:

  • To elucidate the dual role of DDX17 in viral infections.
  • To explore the potential of DDX17 as an antiviral therapeutic target.

Main Methods:

  • The study reviews existing literature on DDX17's function in various viral infections.
  • Analysis of DDX17's interactions with viral components and its impact on viral RNA metabolism.

Main Results:

  • DDX17 can enhance viral RNA stability, packaging, and replication (e.g., influenza, Hantaan virus).
  • DDX17 can also inhibit viral proliferation by disrupting viral RNA metabolism (e.g., hepatitis B virus, Epstein-Barr virus).

Conclusions:

  • DDX17 exhibits context-dependent, dual functionality in host-virus interactions.
  • DDX17 represents a promising target for developing novel antiviral strategies.