Determinants of intertransfusion interval in children with transfusion-dependent thalassemia: a retrospective single-center cohort study in China
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View abstract on PubMed
Summary
This summary is machine-generated.Genotype severity and red blood cell product type significantly impact transfusion intervals in pediatric transfusion-dependent thalassemia (TDT). Personalized transfusion strategies can optimize treatment and reduce complications for these young patients.
Area Of Science
- Pediatric Hematology
- Transfusion Medicine
- Thalassemia Research
Background
- Optimizing blood transfusion regimens is critical for managing children with transfusion-dependent thalassemia (TDT).
- Identifying factors influencing transfusion intervals is essential for improving patient care and treatment efficacy.
Purpose Of The Study
- To determine the key factors affecting intertransfusion intervals in pediatric patients with TDT.
- To analyze the impact of patient demographics, genotype, and red blood cell (RBC) product characteristics on transfusion frequency.
Main Methods
- A retrospective observational study of 21 pediatric β-thalassemia patients and 392 transfusions.
- Analysis included univariate tests, correlation analysis, and binary logistic regression to identify determinants of intertransfusion intervals.
- Multivariable linear regression evaluated factors influencing pre-transfusion hemoglobin levels.
Main Results
- Genotype severity (major vs. minor) and RBC product type (leukocyte-reduced RBC vs. washed RBC) independently influenced intertransfusion intervals.
- Age and weight negatively correlated with intertransfusion intervals.
- Patients with major genotypes had significantly lower pre-transfusion hemoglobin levels; leukocyte-reduced RBCs showed a hemoglobin advantage over washed RBCs.
Conclusions
- Genotype severity and RBC product type are significant determinants of intertransfusion intervals in pediatric TDT.
- Personalized transfusion strategies considering these factors are recommended for optimizing efficacy and minimizing complications.
- Adverse reactions, including febrile reactions and alloimmunization, were observed in 23.8% of patients.
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