Related Experiment Video
Updated: Jan 9, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
Estimated Prevalence of Substance Use Disorders Among US Adolescents and Emerging Adults by Substance Class,
Zachary W Adams1, Trey V Dellucci1, Jon Agley2
1Indiana University School of Medicine, Indianapolis, Indiana.
Objective:
Substance use disorders (SUDs) often develop during adolescence, forecasting myriad health problems across the lifespan. Implementing responsive clinical services requires information about the prevalence of SUDs by age, substance class, and severity. However, no reports have summarized those data using DSM-5 criteria.
Method:
Using 2022 National Survey on Drug Use and Health (NSDUH) data from participants 12 to 25 years of age (n = 26,276), the prevalence and severity of DSM-5 SUDs was estimated across age cohorts (12-13, 14-15, 16-17, 18-20, and 21-25 years) via χ2 tests of independence. The Cramer V (φ c ) was also calculated for each outcome to approximate the effect size between age group and substance use outcome.
Results:
Although past-year rates for alcohol and cannabis use were higher overall as age cohort increased, the prevalence of disordered use and proportional distribution of SUD severity (mild, moderate, severe) did not differ across age cohorts among those who used alcohol (φ c = 0.04) and cannabis (φ c = 0.04) in the past year. Conversely, the prevalence and severity of SUDs generally varied across age groups among those who reported past-year use of less commonly used substances (heroin, methamphetamine).
Conclusion:
Meeting criteria for an SUD was common among youth with past-year substance use. Allocation of developmentally appropriate prevention and treatment resources should account for the distribution of mild to severe SUDs across adolescence. The field would likely benefit from further study of these issues in diverse samples.
More Related Videos
Related Concept Videos
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Drug Classes and Categories
Drug Abuse and Addiction: Pharmacological Phenomena
An Overview of Psychoactive Drugs
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Diagnostic and Statistical Manual of Mental Disorders (DSM)
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

