Related Experiment Video
Updated: Jan 9, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Clinical efficacy of platelet-rich fibrin in chronic wound healing: a retrospective study
Zhou Lin1, Yanping Zhang1, Liqin Fu1
1Department of Burns and Plastic Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China.
Objective:
This retrospective cohort study evaluated the clinical effectiveness of platelet-rich fibrin (PRF) versus conventional therapy in chronic wound management.
Methods:
Electronic health records from a single institution (2010-2020) were analyzed. Included patients were adults (≥18 years) diagnosed with a chronic wound and treated with either PRF or conventional therapy.
Results:
Wound healing was faster in the PRF group (36.2 ± 9.3 days vs. 60.4 ± 11.4 days, p < .001). Multivariate Cox regression identified PRF as an independent factor for accelerated healing (HR = 0.61, 95% CI: 0.52-0.72, p = .001). Wound closure (89.8% vs. 70.6%, p < .001) and complete re-epithelialization (90.3% vs. 69.6%, p < .001) were higher in the PRF group. Wound recurrence (10.1% vs. 25.1%, p = .029) and scar formation (12.4% vs. 28.7%, p = .008) were lower in the PRF group. The incidence of adverse events was similar between groups (8.7% vs. 10.4%, p = .582).
Conclusion:
PRF therapy accelerates chronic wound healing, improves healing quality by reducing recurrence and scarring, and demonstrates a safety profile comparable to conventional care.
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