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Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Cutaneous Squamous Cell

Toshihiro Takai1, Takafumi Kadono2, Noriki Fujimoto3

  • 1Department of Dermatology, Hyogo Cancer Center, Akashi, Japan.

The Journal of Dermatology
|December 10, 2025
PubMed

Insights

This study presents evidence-based clinical practice guidelines for cutaneous squamous cell carcinoma (cSCC) treatment. The guidelines cover early lesion management, surgical options, lymph node biopsy, non-surgical alternatives, follow-ups, and advanced stage drug treatments for cSCC.

Area of Science:

  • Dermatology
  • Oncology
  • Evidence-Based Medicine

Background:

  • Cutaneous squamous cell carcinoma (cSCC) is a significant skin cancer.
  • Existing treatment protocols require comprehensive, evidence-based updates.
  • The Japanese Dermatological Association (JDA) recognized the need for revised guidelines.

Purpose of the Study:

  • To develop comprehensive, evidence-based clinical practice guidelines for cSCC.
  • To provide standardized recommendations for cSCC management in Japan and globally.
  • To address key clinical questions regarding cSCC treatment pathways.

Main Methods:

  • Systematic literature review and synthesis by a committee of experts.
  • Recommendations formulated using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) scheme.
  • Adherence to the "Minds Clinical Practice Guideline Preparation Manual 2020 ver. 3.0".

Main Results:

  • Six critical clinical questions (CQs) on cSCC were established.
  • Recommendations were developed for early lesion treatment, reduction surgery, sentinel lymph node biopsy, non-surgical options, post-treatment follow-ups, and advanced stage drug therapy.
  • Guidelines provide a structured approach to cSCC management.

Conclusions:

  • The JDA Clinical Practice Guidelines for Cutaneous Squamous Cell Carcinoma offer a robust framework for patient care.
  • These guidelines aim to enhance the quality of cSCC treatment and improve patient outcomes.
  • The evidence-based recommendations are expected to impact cSCC management worldwide.
Keywords:
Japanclinical guidelinescutaneous squamous cell carcinomasystematic review

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