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Published on: May 2, 2025
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Unplanned Hospitalization Due to All-Cause Morbidity and Its Real-World Management Practices in Patients With Fontan
Hideo Ohuchi1, Kohta Takei2, Jun Muneuchi3
1Department of Pediatric Cardiology and Adult Congenital Heart Disease Center National Cerebral and Cardiovascular Center Suita Japan.
Journal of the American Heart Association
|December 10, 2025
Summary
Unplanned hospitalizations (UPH) in Fontan circulation patients are common, often due to heart failure or protein-losing enteropathy. In-hospital management strategies significantly impact readmission risk, necessitating further research for standardized care.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Congenital Heart Disease Management
Background:
- Unplanned hospitalizations (UPH) management in Fontan circulation patients lacks characterization.
- Understanding UPH drivers and outcomes is crucial for this complex patient group.
Purpose of the Study:
- To characterize unplanned hospitalizations (UPH) in Fontan patients.
- To identify associations between in-hospital management and post-discharge outcomes.
Main Methods:
- Prospective follow-up of 3226 Fontan patients over 3 years.
- Analysis of UPH causes, in-hospital treatments, and readmission data.
Main Results:
- 243 UPHs occurred, with heart failure, protein-losing enteropathy, and hemorrhage as primary Fontan-related causes.
- Readmissions were frequent, driven by protein-losing enteropathy, heart failure, and hemorrhage.
- In-hospital interventions like oxygen therapy, surgery, and diuretic adjustment correlated with readmission risk.
Conclusions:
- Real-world UPH practices in Fontan patients were elucidated.
- Specific in-hospital treatments are linked to readmission risk.
- Further research is needed to establish causal links for standardized management strategies.
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