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Related Concept Videos

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
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Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication

Isabella Goodwin1, Kit Melissa Larsen2, Arshiya Sangchooli1,3

  • 1Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.

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|December 10, 2025
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Summary
This summary is machine-generated.

This study found no link between white matter microstructure and sub-clinical psychotic experiences in healthy individuals. These findings suggest that white matter changes may only appear at clinical psychosis thresholds.

Keywords:
diffusion‐weighted imagingfixel‐based analysispsychotic‐like experienceswhite matter

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Structural white matter deficits are associated with psychosis.
  • It's unclear if these changes occur in individuals with non-clinical psychotic-like experiences before illness onset.
  • Previous studies have limitations, including dichotomizing samples and not accounting for complex fiber populations.

Purpose of the Study:

  • To investigate the association between psychotic-like experiences and white matter microstructure in healthy individuals.
  • To determine if Fixel-Based Analysis (FBA) metrics are sensitive to microstructural and morphological effects in white matter related to psychotic-like experiences.

Main Methods:

  • Treated psychotic-like experiences as a continuous variable.
  • Applied Fixel-Based Analysis (FBA) to diffusion-weighted imaging data from two independent cohorts of healthy participants (total n=1139).
  • Analyzed whole-brain and tract-aggregated data, using Bayesian analysis to assess the evidence for association.

Main Results:

  • No significant correlations were found between psychotic-like experiences and FBA metrics in either cohort.
  • Bayesian analysis provided substantial evidence for no association between psychotic-like experiences and white matter fiber density or morphology.
  • This lack of association was consistent across tract-aggregated data and pre-defined white matter tracts of interest.

Conclusions:

  • The relationship between non-clinical psychotic-like experiences and white matter microstructure may not be as robust as previously assumed.
  • White matter alterations might be specific to clinical psychosis, appearing only above diagnostic thresholds.
  • Future longitudinal studies are needed to explore the predictive value of white matter attributes for psychosis risk.