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Published on: October 16, 2015
Ultrasmall glutathione-protected Au/Cu and their alloy nanoclusters with specific ROS generation
Ling Chen1, Tianfeng Pan1, Jing Jin1
1Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui 230601, China.
Abstract:
In this study, three glutathione (GSH)-protected nanoclusters ([Au5(SG)3]-, [Au9Cu2(SG)7]3- and [Cu7(SG)5]3+) were synthesized and characterized by ESI-MS, EPR, NMR and XPS. Each cluster exhibits a specificity in generating a distinct reactive oxygen species (ROS), specifically hydroxyl radicals (˙OH), singlet oxygen (1O2), or superoxide anions (O2˙-), under ambient conditions. This unique performance highlights not only the clusters' structural and functional specificity in ROS generation, but also their promising potential for advancing bioclinical applications.
