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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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mRNA-based therapies: current progress and future prospects for treating kidney disease.

Yiyun Song1, Hua Su2

  • 1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Clinical and Experimental Nephrology
|December 10, 2025
PubMed
Summary

Chronic kidney disease causes over a million deaths annually. This review explores messenger RNA (mRNA) therapies as a promising new avenue for treating kidney diseases, offering potential alternatives to current limited options.

Keywords:
Kidney diseaseProtein replacementmRNA-based therapy

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Area of Science:

  • Nephrology
  • Molecular Biology
  • Biotechnology

Background:

  • Chronic kidney disease (CKD) affects millions globally, with increasing incidence and limited treatment efficacy.
  • Current treatments often lead to kidney replacement therapy, highlighting the need for novel therapeutic approaches.
  • Messenger RNA (mRNA) technology has emerged as a powerful tool in molecular therapy with potential clinical applications.

Purpose of the Study:

  • To review recent advancements in mRNA-based therapies for kidney diseases.
  • To discuss the future potential of mRNA applications in treating renal conditions.
  • To provide an overview of the evolving landscape of mRNA in nephrology.

Main Methods:

  • Literature review of recent studies on renal mRNA-based therapies.
  • Analysis of emerging trends and future directions in the field.
  • Synthesis of current knowledge on mRNA applications in kidney disease.

Main Results:

  • mRNA-based therapies are beginning to show promise in the kidney field.
  • Recent advances highlight the potential of mRNA for treating various renal pathologies.
  • The review consolidates current understanding and future prospects of mRNA in nephrology.

Conclusions:

  • mRNA-based therapies represent a significant advancement in the treatment of kidney diseases.
  • Further research and development hold promise for novel mRNA-driven interventions.
  • mRNA technology offers a potential paradigm shift in managing chronic kidney disease.