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Updated: Jan 7, 2026
High Resolution 3D Imaging of Ex-Vivo Biological Samples by Micro CT
Published on: June 21, 2011
Differentiation of tumor budding grade in colon cancer using noise-optimized virtual monoenergetic image in
Changjiu He1, Chuanyang Shao1, Jieke Liu1
1Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.
Objective:
To evaluate the value of noise-optimized virtual monoenergetic image (VMI+) in dual-energy CT (DECT) in predicting tumor budding (TB) grade in colon cancer.
Methods:
Seventy-six patients with pathologically confirmed colon cancer who underwent contrast-enhanced DECT were retrospectively enrolled and were divided into low/intermediate-grade TB (n = 52) and high-grade TB groups (n = 24). The contrast-to-noise ratio (CNR), overall image quality, and lesion delineation were evaluated on VMI+ (40-0 keV with an interval of 10 keV). The DECT quantitative parameters were analyzed, including attenuation of VMI+, iodine concentration (IC), normalized IC (NIC), electron density (Rho), and effective atomic number (Zeff). The diagnostic performance in differentiating TB grade in colon cancer was evaluated using the area under the curve (AUC).
Results:
40 keV, 50 keV, and 60 keV showed good diagnostic performance in differentiating TB grade (AUC: 0.825, 0.833, and 0.843; sensitivity: 0.708, 0.708, and 0.750; specificity: 0.904, 0.904, and 0.846; cutoff value: 179.5 HU, 129.9 HU, and 101.2 HU) and had significantly higher AUC than IC (0.770), NIC (0.647), Rho (0.642), and Zeff (0.785) (all P < 0.05). 40 keV had the best lesion delineation and provided significantly higher CNR than other VMI + levels, while 60 keV provided better overall image quality than other VMI + levels (all corrected P < 0.05).
Conclusions:
The DECT-derived low-keV VMI+ (40 keV, 50 keV, and 60 keV) provided better diagnostic performance in differentiating TB grade in colon cancer. 40 keV showed better CNR and lesion delineation, while 60 keV provided better overall image quality.
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